Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide

被引：113

作者：

Fowler, CJ ^{[1
]}

Jonsson, KO ^{[1
]}

Tiger, G ^{[1
]}

机构：

[1] Umea Univ, Dept Pharmacol & Clin Neurosci, SE-90187 Umea, Sweden

来源：

BIOCHEMICAL PHARMACOLOGY | 2001年 / 62卷 / 05期

关键词：

anandamide; palmitoylethanolamide; oleamide; fatty acid amide hydrolase;

D O I：

10.1016/S0006-2952(01)00712-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of a number of important endogenous fatty acid amides, including the endogenous cannabimimetic agent anandamide (AEA), the sleep-inducing compound oleamide, and the putative anti-inflammatory agent palmitoylethanolamide (PEA). In recent years, there have been great advances in our understanding of the biochemical and pharmacological properties of the enzyme. In this commentary, the structure and biochemical properties of FAAH and the development of potent and selective FAAH inhibitors are reviewed, together with a brief discussion on the therapeutic possibilities for such compounds in the treatment of inflammatory pain and ischaemic states. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：517 / 526

页数：10

共 88 条

[11]

Bobrov MY, 2000, BIOCHEMISTRY-MOSCOW+, V65, P615

[12] Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide [J].

Boger, DL ;

Sato, H ;

Lerner, AE ;

Hedrick, MP ;

Fecik, RA ;

Miyauchi, H ;

Wilkie, GD ;

Austin, BJ ;

Patricelli, MP ;

Cravatt, BF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5044-5049

[13] Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: A probe of structural and conformational features contributing to inhibition [J].

Boger, DL ;

Sato, H ;

Lerner, AE ;

Austin, BJ ;

Patterson, JE ;

Patricelli, MP ;

Cravatt, BF .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (02) :265-270

[14]

Boger DL, 1998, CURR PHARM DESIGN, V4, P303

[15] Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid [J].

Braud, S ;

Bon, C ;

Touqui, L ;

Mounier, C .

FEBS LETTERS, 2000, 471 (01) :12-16

[16] Oxidative metabolism of anandamide [J].

Burstein, SH ;

Rossetti, RG ;

Yagen, B ;

Zurier, RB .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2000, 61 (1-2) :29-41

[17] Control of pain initiation by endogenous cannabinoids [J].

Calignano, A ;

La Rana, G ;

Giuffrida, A ;

Piomelli, D .

NATURE, 1998, 394 (6690) :277-281

[18] Study of the amidase signature group [J].

Chebrou, H ;

Bigey, F ;

Arnaud, A ;

Galzy, P .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1996, 1298 (02) :285-293

[19]

Compton DR, 1997, J PHARMACOL EXP THER, V283, P1138

[20] Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides [J].

Cravatt, BF ;

Giang, DK ;

Mayfield, SP ;

Boger, DL ;

Lerner, RA ;

Gilula, NB .

NATURE, 1996, 384 (6604) :83-87

← 1 2 3 4 5 6 7 8 9 →