Nuclear gene transcription and chromatin in Trypanosoma brucei

被引：19

作者：

Horn, D ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 11期

基金：

英国惠康基金;

关键词：

transcription; Trypanosoma brucei; VSG;

D O I：

10.1016/S0020-7519(01)00264-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells, Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here. I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1157 / 1165

页数：9

共 75 条

[1] Gene regulation - Insulators and boundaries: Versatile regulatory elements in the eukaryotic genome [J].

Bell, AC ;

West, AG ;

Felsenfeld, G .

SCIENCE, 2001, 291 (5503) :447-450

[2] TRYPANOSOME NUCLEAR FACTORS WHICH BIND TO INTERNAL PROMOTER ELEMENTS OF TRANSFER-RNA GENES [J].

BELL, SD ;

BARRY, JD .

NUCLEIC ACIDS RESEARCH, 1995, 23 (16) :3103-3110

[3] Chromatin remodelling during the life cycle of trypanosomatids [J].

Belli, SI .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2000, 30 (06) :679-687

[4] SEQUENCE DIFFERENCES BETWEEN HISTONES OF PROCYCLIC TRYPANOSOMA-BRUCEI-BRUCEI AND HIGHER EUKARYOTES [J].

BENDER, K ;

BETSCHART, B ;

SCHALLER, J ;

KAMPFER, U ;

HECKER, H .

PARASITOLOGY, 1992, 105 :97-104

[5] A single-stranded DNA-binding protein shared by telomeric repeats, the variant surface glycoprotein transcription promoter and the procyclin transcription terminator of Trypanosoma brucei [J].

Berberof, M ;

Vanhamme, L ;

Alexandre, S ;

Lips, S ;

Tebabi, P ;

Pays, E .

NUCLEIC ACIDS RESEARCH, 2000, 28 (02) :597-604

[6]

Berberof M, 1996, MOL CELL BIOL, V16, P914

[7] Analysis of a variant surface glycoprotein gene expression site promoter of Trypanosoma brucei by remodelling the promoter region [J].

Blundell, PA ;

Borst, P .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 94 (01) :67-85

[8] The many HATs of transcription coactivators [J].

Brown, CE ;

Lechner, T ;

Howe, L ;

Workman, JL .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (01) :15-19

[9] PARTIAL AMINO-ACID-SEQUENCE AND FUNCTIONAL-ASPECTS OF HISTONE H1 PROTEINS IN TRYPANOSOMA-BRUCEI-BRUCEI [J].

BURRI, M ;

SCHLIMME, W ;

BETSCHART, B ;

LINDNER, H ;

KAMPFER, U ;

SCHALLER, J ;

HECKER, H .

BIOLOGY OF THE CELL, 1995, 83 (01) :23-31

[10]

CHAPMAN AB, 1994, J BIOL CHEM, V269, P4754

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