Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring

被引：18

作者：

Taylor, C

Quinn, RJ

Suganuma, M

Fujiki, H

机构：

[1] GRIFFITH UNIV,QUEENSLAND PHARMACEUT RES INST,BRISBANE,QLD 4111,AUSTRALIA

[2] SAITAMA CANC CTR,RES INST,INA,SAITAMA 362,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 17期

关键词：

D O I：

10.1016/0960-894X(96)00378-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several synthetic analogues of microcystin-LR and nodularin at 1 mM inhibited PP2A. The active microcystin analogues were cyclic heptapeptides envisaged to interact with the catalytic subunit of PP1 and PP2A when an Adda-type hydrophobic group was added. The cyclic core was found to have some intrinsic phosphatase inhibitory activity. Copyright (C) 1996 Elsevier Science Ltd

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页码：2113 / 2116

页数：4

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