THE ROLE OF ARGININE IN INTERACTIONS OF MICROCYSTINS WITH PROTEIN PHOSPHATASE-1 AND PHOSPHATASE-2A

被引：11

作者：

NISHIWAKIMATSUSHIMA, R

FUJIKI, H

HARADA, K

TAYLOR, C

QUINN, RJ

机构：

[1] MEIJO UNIV,FAC PHARM,NAGOYA,AICHI 468,JAPAN

[2] GRIFFITH UNIV,SCH SCI,NATHAN,QLD 4111,AUSTRALIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(00)80388-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Comparison of the enzyme inhibition and receptor binding activity of microcystin-LR and microcystin-LA has shown that the arginine residue in microcystin-LR does not significantly contribute to biological activity. This data allows a refinement of a receptor binding model of the okadaic acid class of protein phosphatase inhibitors.

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页码：673 / 676

页数：4

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