A practical synthetic approach to chiral α-aryl substituted ethylphosphonates

被引：79

作者：

Goulioukina, NS

Dolgina, TM

Beletskaya, IP

Henry, JC

Lavergne, D

Ratovelomanana-Vidal, V

Genet, JP

机构：

[1] Moscow State Univ, Dept Chem, Moscow 119899, Russia

[2] Ecole Natl Super Chim, UMR CNRS 7573, Lab Synth Select Organ & Prod Nat, F-75231 Paris 05, France

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1016/S0957-4166(01)00031-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A convenient general method is reported for the synthesis of alpha -aryl substituted ethylphosphonic acids and esters by hydrogenation of alpha -aryl substituted ethenylphosphonic acids and esters. Racemic alpha -arylethylphosphonic acids and esters were prepared in 70-88%, yield under palladium-assisted transfer hydrogenation conditions using ammonium formate. Asymmetric hydrogenation of alpha -arylethenylphosphonic acids using chiral Ru(II) catalysts led to alpha -arylethylphosphonic acids with enantiomeric excesses up to 86%. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：319 / 327

页数：9

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