An improved synthesis of N-[(9-hydroxymethyl)-2-fluorenyl]succinamic acid (HMFS), a versatile handle for the solid-phase synthesis of biomolecules

被引:15
作者
Albericio, F [1 ]
Cruz, M [1 ]
Debéthune, L [1 ]
Eritja, R [1 ]
Giralt, E [1 ]
Grandas, A [1 ]
Marchán, V [1 ]
Pastor, JJ [1 ]
Pedroso, E [1 ]
Rabanal, F [1 ]
Royo, M [1 ]
机构
[1] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain
关键词
D O I
10.1081/SCC-100000203
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The optimization of a synthetic process for the preparation of HMFS handle, which is used for the solid-phase synthesis of peptides and oligonucleotides, is presented.
引用
收藏
页码:225 / 232
页数:8
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