PGEToolbox: A matlab toolbox for population genetics and evolution

被引:23
作者
Cai, James J. [1 ]
机构
[1] Stanford Univ, Dept Biol, Stanford, CA 94305 USA
关键词
D O I
10.1093/jhered/esm127
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Assessing genetic diversity within populations is vital for understanding the nature of evolutionary processes at the molecular level. PGEToolbox is a Matlab-based open-sourced software package for data analysis in population genetics. The main features of this software are as follows: 1) capability for handling both DNA sequence polymorphisms and single nucleotide polymorphisms (SNPs), which include genotype and haplotype data; 2) exhaustive population genetic analyses and neutrality tests based on the coalescent theory; 3) extendibility and scalability for complex and large genome-wide datasets; 4) simple yet effective graphic user interfaces and sophisticated visualization of data and results. For academic uses, PGEToolbox is available free of charge at http://bioinformatics.org/pgetoolbox.
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收藏
页码:438 / 440
页数:3
相关论文
共 35 条
[11]   The International HapMap Project [J].
Gibbs, RA ;
Belmont, JW ;
Hardenbol, P ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Ch'ang, LY ;
Huang, W ;
Liu, B ;
Shen, Y ;
Tam, PKH ;
Tsui, LC ;
Waye, MMY ;
Wong, JTF ;
Zeng, CQ ;
Zhang, QR ;
Chee, MS ;
Galver, LM ;
Kruglyak, S ;
Murray, SS ;
Oliphant, AR ;
Montpetit, A ;
Hudson, TJ ;
Chagnon, F ;
Ferretti, V ;
Leboeuf, M ;
Phillips, MS ;
Verner, A ;
Kwok, PY ;
Duan, SH ;
Lind, DL ;
Miller, RD ;
Rice, JP ;
Saccone, NL ;
Taillon-Miller, P ;
Xiao, M ;
Nakamura, Y ;
Sekine, A ;
Sorimachi, K ;
Tanaka, T ;
Tanaka, Y ;
Tsunoda, T ;
Yoshino, E ;
Bentley, DR ;
Deloukas, P ;
Hunt, S ;
Powell, D ;
Altshuler, D ;
Gabriel, SB ;
Qiu, RZ .
NATURE, 2003, 426 (6968) :789-796
[12]   Screening for recently selected alleles by analysis of human haplotype similarity [J].
Hanchard, NA ;
Rockett, KA ;
Spencer, C ;
Coop, G ;
Pinder, M ;
Jallow, M ;
Kimber, M ;
McVean, G ;
Mott, R ;
Kwiatkowski, DP .
AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (01) :153-159
[13]   Novel multilocus measure of linkage disequilibrium to estimate past effective population size [J].
Hayes, BJ ;
Visscher, PM ;
McPartlan, HC ;
Goddard, ME .
GENOME RESEARCH, 2003, 13 (04) :635-643
[14]   Whole-genome patterns of common DNA variation in three human populations [J].
Hinds, DA ;
Stuve, LL ;
Nilsen, GB ;
Halperin, E ;
Eskin, E ;
Ballinger, DG ;
Frazer, KA ;
Cox, DR .
SCIENCE, 2005, 307 (5712) :1072-1079
[15]   Generating samples under a Wright-Fisher neutral model of genetic variation [J].
Hudson, RR .
BIOINFORMATICS, 2002, 18 (02) :337-338
[16]  
HUDSON RR, 1985, GENETICS, V111, P147
[17]  
Kelly JK, 1997, GENETICS, V146, P1197
[18]   ADAPTIVE PROTEIN EVOLUTION AT THE ADH LOCUS IN DROSOPHILA [J].
MCDONALD, JH ;
KREITMAN, M .
NATURE, 1991, 351 (6328) :652-654
[19]  
Nei M., 1987, Science, Philosophy and Human Behavior in the Soviet Union
[20]   Genomic scans for selective sweeps using SNP data [J].
Nielsen, R ;
Williamson, S ;
Kim, Y ;
Hubisz, MJ ;
Clark, AG ;
Bustamante, C .
GENOME RESEARCH, 2005, 15 (11) :1566-1575