Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports

被引：83

作者：

Cushnie, TPT ^{[1
]}

Hamilton, VES ^{[1
]}

Lamb, AJ ^{[1
]}

机构：

[1] Robert Gordon Univ, Sch Pharm, Aberdeen AB10 1FR, Scotland

来源：

MICROBIOLOGICAL RESEARCH | 2003年 / 158卷 / 04期

关键词：

flavonoids; antibacterial activity; apigenin; galangin; baicalin; S; aureus;

D O I：

10.1078/0944-5013-00206

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Activity of the flavonoids apigenin, baicalin and galangin against sensitive and antibiotic resistant strains of Staphylococcus aureus, Enterococcus faecalis, E. faecium, Escherichia coli and Pseudomonas aeruginosa was investigated. Using an agar dilution assay, galangin was shown to have a minimum inhibitory concentration (MIC) of 25 to 50 mug/mL against all six strains of S. aureus but negligible activity against the other species. Apigenin displayed only marginal activity against S. aureus and no activity was detected from baicalin. In inhibition curve studies, galangin caused a 100,000-fold decrease in the viability of a growing population of S. aureus NCTC 6571 within the first two hours of treatment. Decreases in viability of S. aureus NCTC 11561 and NCIMB 9968 populations were also observed.

引用

页码：281 / 289

页数：9

共 34 条

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