Carboxylate-Assisted Ruthenium-Catalyzed Direct Alkylations of Ketimines

被引：183

作者：

Ackermann, Lutz ^{[1
]}

Hofmann, Nora ^{[1
]}

Vicente, Ruben ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 07期

关键词：

H BOND FUNCTIONALIZATION; C-H; DIRECT ARYLATIONS; CARBON-HYDROGEN; ALKYL-HALIDES; METAL; PALLADIUM; ACTIVATION; CLEAVAGES; ELECTROPHILES;

D O I：

10.1021/ol200366n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The mechanism of carboxylate-assisted ruthenium(II)-catalyzed direct aikylations of ketimines with unactivated alkyl halides was probed through experimental studies. The remarkable chemoselectivity of the broadly applicable catalyst also enabled direct alkylations among others on H2O or under solvent-free reaction conditions.

引用

页码：1875 / 1877

页数：3

共 45 条

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[J]. ORGANIC LETTERS, 2010, 12 (04) : 724 - 726

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