Genetic contributions to stability and change in intelligence from childhood to old age

被引：189

作者：

Deary, Ian J. ^{[1
,2
]}

Yang, Jian ^{[3
]}

Davies, Gail ^{[1
,2
]}

Harris, Sarah E. ^{[2
,4
]}

Tenesa, Albert ^{[4
,5
]}

Liewald, David ^{[1
,2
]}

Luciano, Michelle ^{[1
,2
]}

Lopez, Lorna M. ^{[1
,2
]}

Gow, Alan J. ^{[1
,2
]}

Corley, Janie ^{[1
]}

Redmond, Paul ^{[1
,7
]}

Fox, Helen C.

Rowe, Suzanne J. ^{[5
]}

Haggarty, Paul

McNeill, Geraldine ^{[6
]}

Goddard, Michael E. ^{[8
,9
]}

Porteous, David J. ^{[2
,4
]}

Whalley, Lawrence J. ^{[6
]}

Starr, John M. ^{[2
,10
]}

Visscher, Peter M. ^{[2
,3
,11
,12
]}

机构：

[1] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

[3] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[4] Western Gen Hosp, Inst Genet & Mol Med, Med Genet Sect, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[5] Univ Edinburgh, Sch Vet Studies, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotland

[6] Inst Appl Hlth Sci, Aberdeen AB25 2ZD, Scotland

[7] Univ Aberdeen, Rowett Inst Nutr & Hlth, Nutr & Epigenet Grp, Aberdeen AB21 9SB, Scotland

[8] Australia & Victorian Dept Primary Ind, Bundoora, Vic 3083, Australia

[9] Univ Melbourne, Dept Food & Agr Syst, Parkville, Vic 3011, Australia

[10] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland

[11] Univ Queensland, Diamantina Inst, Princess Alexandra Hosp, Brisbane, Qld 4102, Australia

[12] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

来源：

NATURE | 2012年 / 482卷 / 7384期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 澳大利亚研究理事会;

关键词：

COMMON SNPS EXPLAIN; LATER LIFE; COGNITIVE DECLINE; LARGE PROPORTION; HUMAN HEIGHT; HERITABILITY; ABILITIES; VARIANCE; MODELS;

D O I：

10.1038/nature10781

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding the determinants of healthy mental ageing is a priority for society today(1,2). So far, we know that intelligence differences show high stability from childhood to old age(3,4) and there are estimates of the genetic contribution to intelligence at different ages(5,6). However, attempts to discover whether genetic causes contribute to differences in cognitive ageing have been relatively uninformative(7-10). Here we provide an estimate of the genetic and environmental contributions to stability and change in intelligence across most of the human lifetime. We used genome-wide single nucleotide polymorphism (SNP) data from 1,940 unrelated individuals whose intelligence was measured in childhood (age 11 years) and again in old age (age 65, 70 or 79 years)(11,12). We use a statistical method that allows genetic (co)variance to be estimated from SNP data on unrelated individuals(13-17). We estimate that causal genetic variants in linkage disequilibrium with common SNPs account for 0.24 of the variation in cognitive ability change from childhood to old age. Using bivariate analysis, we estimate a genetic correlation between intelligence at age 11 years and in old age of 0.62. These estimates, derived from rarely available data on lifetime cognitive measures, warrant the search for genetic causes of cognitive stability and change.

引用

页码：212 / 215

页数：4

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