Systemic Hypothermia for the Treatment of Acute Cervical Spinal Cord Injury in Sports

被引：18

作者：

Dietrich, William Dalton ^{[1
]}

Cappuccino, Andrew ^{[2
,3
]}

Cappuccino, Helen ^{[4
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami Project Cure Paralysis, Miami, FL 33136 USA

[2] Buffalo Spine Surg, Lockport, NY USA

[3] Team Orthoped Surg Buffalo Bills, Buffalo, NY USA

[4] SUNY Buffalo, Sch Med & Biomed Sci, Roswell Pk Canc Inst, Buffalo, NY 14260 USA

来源：

CURRENT SPORTS MEDICINE REPORTS | 2011年 / 10卷 / 01期

关键词：

THERAPEUTIC HYPOTHERMIA; LOCOMOTOR FUNCTION; PATHOPHYSIOLOGY; CONTUSION;

D O I：

10.1249/JSR.0b013e318205e0b3

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Spinal cord injury is a devastating condition that affects approximately 12,000 patients each year in the United States. Major causes for spinal cord injury include motor vehicle accidents, sports-related injuries, and direct trauma. Moderate hypothermia has gained attention as a potential therapy due to recent experimental and clinical studies and the use of modest systemic hypothermia (MSH) in high profile case of spinal cord injury in a National Football League (NFL) player. In experimental models of spinal cord injury, moderate hypothermia has been shown to improve functional recovery and reduce overall structural damage. In a recent Phase I clinical trial, systemic hypothermia has been shown to be safe and provide some encouraging results in terms of functional recovery. This review will summarize recent preclinical data, as well as clinical findings that support the continued investigations for the use of hypothermia in severe cervical spinal cord injury.

引用

页码：50 / 54

页数：5

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