Leukemogenesis of the EVI1/MEL1 gene family

被引：35

作者：

Morishita, Kazuhiro ^{[1
]}

机构：

[1] Miyazaki Univ, Fac Med, Dept Med Sci, Div Tumor & Cellular Biochem, Miyazaki 8891692, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 85卷 / 04期

关键词：

EVI1; MEL1; leukemogenesis; chromosomal rearrangement; PR domain; hematopoiesis; gene expression;

D O I：

10.1532/IJH97.06174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leukemia is a group of monoclonal diseases that arise from hematopoietic stem and progenitor cells in the bone marrow or other hematopoietic organs. Retroviral infections are one of the major events leading to leukemogenesis in mice, because retroviruses can induce hematopoietic disease via the insertional mutagenesis of oncogenes; therefore, the cloning of viral-integration sites in murine leukemia has provided valuable molecular tags for oncogene discovery. Transcription of the murine gene ecotropic viral-integration site 1 (Evil) is activated by nearby viral integration. In humans, the Evil homologue EVI1 is activated by chromosomal translocations. Ibis review discusses the roles of the overexpression of EVI1/MEL1 gene family members in leukemogenesis, the relationships of various translocations in EVI1 overexpression, and the importance of PR domains in tumor suppression and oncogenesis. The functions of EVI1/MEL1 members as transcription factors and the concept of EVI1 -positive leukemia as a stem cell disease are also reviewed.

引用

页码：279 / 286

页数：8

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