Layer-by-Layer Assembled Multilayer Films of Methoxypoly(ethylene glycol)-block-poly(α,L-glutamic acid) and Chitosan with Reduced Cell Adhesion

被引：11

作者：

Cao, Bin ^{[2
]}

Yan, Shifeng ^{[2
]}

Zhang, Kunxi ^{[2
]}

Song, Zhijiang ^{[2
]}

Chen, Xuesi ^{[1
]}

Cui, Lei ^{[3
]}

Yin, Jingbo ^{[2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[2] Shanghai Univ, Dept Polymer Mat, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Plast & Reconstruct Surg, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 09期

基金：

中国国家自然科学基金;

关键词：

cell adhesion; coatings; layer growth; multilayer films; poly(L-glutamic acid); POLY(ACRYLIC ACID); MOLECULAR-WEIGHT; STEM-CELLS; GROWTH; SURFACE; COPOLYMER; DELIVERY; BUILDUP; TISSUE;

D O I：

10.1002/mabi.201100053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A methoxypoly(ethylene glycol)-block-poly(alpha,L-glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA)(n) film construction takes place over two build-up stages (exponential-to-linear). UV-vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film-modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.

引用

页码：1211 / 1217

页数：7

共 38 条

[1]

Polyelectrolyte multilayer films with pegylated polypeptides as a new type of anti-microbial protection for biomaterials [J].