Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model

被引：20

作者：

da Silva, TC

da Silva, AP

Akisue, G

Avanzo, JL

Nagamine, MK

Fukumasu, H

Matsuzaki, P

Raspantini, PC

Haraguchi, M

Górniak, SL

Dagli, MLZ

机构：

[1] Univ Sao Paulo, Fac Vet Med & Zootech, Dept Pathol, BR-05508900 Sao Paulo, Brazil

[2] Univ Sao Francisco, Fac Pharmaceut Sci, Biol Sci Area, Acad Unit, BR-12900000 Braganca Paulista, SP, Brazil

[3] Univ Sao Paulo, Fac Vet Med & Zootech, Dept Pathol, CEPTOX Res Ctr Vet Toxicol, BR-13635900 Pirassununga, SP, Brazil

[4] Biol Inst Sao Paulo, Div Anim Biol, Pharmacol Sect, BR-04014002 Sao Paulo, Brazil

来源：

CANCER LETTERS | 2005年 / 226卷 / 02期

关键词：

hepatocarcinogenesis; Pfaffia paniculata; liver; cancer; chemoprevention;

D O I：

10.1016/j.canlet.2004.12.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated. its chemopreventive effects on preneoplastic hepatic lesions. BALB/c-aged-15 days received 10 mu g/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 or 10% during 27 weeks. After being sacrificed, the macroscopic lesions in the livers were examined. Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps. (C) 2004 Elsevier Ireland Ltd. All tights reserved.

引用

页码：107 / 113

页数：7

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[11] DIETARY PHYTOSTEROLS - A REVIEW OF METABOLISM, BENEFITS AND SIDE-EFFECTS [J].