Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives

被引：19

作者：

Busto, E ^{[1
]}

Gotor-Fernández, V ^{[1
]}

Gotor, V ^{[1
]}

机构：

[1] Univ Oviedo, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 20期

关键词：

D O I：

10.1016/j.tetasy.2005.09.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral 4-(N,N-dimethylamino)pyridine derivatives have been prepared through a chemoenzymatic synthesis where the enzymatic kinetic resolution of a family of 4-chloro-2-(1-hydroxyalkyl)pyridines is the key step for the formation of potentially important chiral catalysts. Pseudomonas cepacia lipase (PSL) showed excellent enantioselectivity in the acylation of the (R)-enantiomers (E > 200) using vinyl acetate as acylating agent and THF as solvent, obtaining products and substrates enantiomerically pure and with excellent yields. (c) 2005 Published by Elsevier Ltd.

引用

页码：3427 / 3435

页数：9

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