IL-7: maintaining T-cell memory and achieving homeostasis

被引：202

作者：

Bradley, LM

Haynes, L

Swain, SL

机构：

[1] Sidney Kimmel Canc Ctr, San Diego, CA 92121 USA

[2] Trudeau Inst, Saranac Lake, NY 12983 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 03期

关键词：

D O I：

10.1016/j.it.2005.01.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During an immune response, peripheral T-cell populations expand and then contract as the response subsides, thus maintaining a fairly constant number of CD4 and CD8 T cells throughout the life of the individual. The important factors that control this homeostasis are now beginning to be understood. Interieukin-7 (IL-7) has emerged as a central regulator of the survival and homeostasis of CD4 and CD8 T cells. Both naive and memory T-cell populations are highly dependent on the presence of IL-7 for their persistence and survival. In this Review, we discuss the role of IL-7 in the survival and homeostasis of naive and memory T cells and how that role is regulated by other factors.

引用

收藏

页码：172 / 176

页数：5

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