A carbazole derivative synthesis for stabilizing the quadruplex structure

被引：48

作者：

Chang, CC ^{[1
]}

Wu, JY ^{[1
]}

Chang, TC ^{[1
]}

机构：

[1] Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2003年 / 50卷 / 02期

关键词：

human telomere; quadruplex stabilizer; biomarker;

D O I：

10.1002/jccs.200300026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new molecule of 3,6-Bis(1-methyl-4-vinylpyridium iodine)carbazole (BMVC) was synthesized for stabilizing the quadruplex structure of human telomeric sequence of d(T(2)AG(3))(4) in vitro. Mixing BMVC with the DNA can raise the melting temperature of the d(T(2)AG(3))(4) by similar to13 degreesC, implying that BMVC could be a useful telomerase inhibitor. In addition, the fluorescence of the BMVC increased significantly upon interacting with the d(T(2)AG(3))(4) which may be useful as a G-quadruplex specific marker.

引用

收藏

页码：185 / 188

页数：4

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