Thiol-independent DNA alkylation by leinamycin

被引：45

作者：

Breydo, L ^{[1
]}

Zang, H ^{[1
]}

Mitra, K ^{[1
]}

Gates, KS ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem & Biochem, Columbia, MO 65211 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 123卷 / 09期

关键词：

D O I：

10.1021/ja003309r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：2060 / 2061

页数：2

共 23 条

[1] Thiol-mediated DNA alkylation by the novel antitumor antibiotic leinamycin [J].

Asai, A ;

Hara, M ;

Kakita, S ;

Kanda, Y ;

Yoshida, M ;

Saito, H ;

Saitoh, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (28) :6802-6803

[2] Thiol-independent DNA cleavage by a leinamycin degradation product [J].

Asai, A ;

Saito, H ;

Saitoh, Y .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (04) :723-729

[3] 1,2-Dithiolan-3-one 1-oxides: A class of thiol-activated DNA-Cleaving agents that are structurally related to the natural product leinamycin [J].

Behroozi, SJ ;

Kim, W ;

Dannaldson, J ;

Gates, KS .

BIOCHEMISTRY, 1996, 35 (06) :1768-1774

[4] REACTION OF N-PROPANETHIOL WITH 3H-1,2-BENZODITHIOL-3-ONE 1-OXIDE AND 5,5-DIMETHYL-1,2-DITHIOLAN-3-ONE 1-OXIDE - STUDIES RELATED TO THE REACTION OF ANTITUMOR ANTIBIOTIC LEINAMYCIN WITH DNA [J].

BEHROOZI, SJ ;

KIM, WK ;

GATES, KS .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (13) :3964-3966

[5] Thiol-dependent DNA cleavage by 3H-1,2-Benzodithiol-3-one 1,1-dioxide [J].

Breydo, L ;

Gates, KS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (09) :885-889

[6] DNA cleavage by 7-methylbenzopentathiepin: A simple analog of the antitumor antibiotic varacin [J].

Chatterji, T ;

Gates, KS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (05) :535-538

[7]

Foye W.O., 1995, Cancer Chemotherapeutic Agents

[8] Mechanisms of DNA damage by leinamycin [J].

Gates, KS .

CHEMICAL RESEARCH IN TOXICOLOGY, 2000, 13 (10) :953-956

[9]

GATES KS, 1999, DNA ASPECTS MOL BIOL, V7, P491

[10]

HENMINKI K, 1994, DNA ADDUCTS IDENTIFI, V125

← 1 2 3 →