Synthesis and DNA damaging ability of enediyne-polyamine conjugates

被引：27

作者：

Suzuki, I ^{[1
]}

Shigenaga, A ^{[1
]}

Nemoto, H ^{[1
]}

Shibuya, M ^{[1
]}

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期

关键词：

D O I：

10.1016/j.tetlet.2003.12.139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyamine-enediyne conjugates were synthesized and exhibited potent DNA damaging ability under physiological conditions. The extent of their activity was shown to depend upon the polyamine length that regulates the DNA binding affinity of the conjugates, and enhanced DNA damaging activities were observed under slightly acidic conditions. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1955 / 1959

页数：5

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