Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization

被引：49

作者：

van Dijk, Maarten

Mustafa, Khalid

Dechesne, Annemarie C.

van Nostrum, Cornelus F.

Hennink, Wim E.

Rijkers, Dirk T. S.

Liskamp, Rob M. J.

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands

[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands

来源：

BIOMACROMOLECULES | 2007年 / 8卷 / 02期

关键词：

BLOCK-COPOLYMERS; CLICK-CHEMISTRY; EFFICIENT ROUTE; AZIDE;

D O I：

10.1021/bm061010g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The optimized reaction conditions for the Cu(I)-catalyzed N -> C polymerization of azido-phenylalanyl-alanyl-propargyl amide to yield either high molecular weight linear polymers or medium-sized cyclic polymers is described. These reaction conditions will be applied to tailor the synthesis, properties, and structure of biologically relevant peptide-based biopolymers.

引用

收藏

页码：327 / 330

页数：4

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