Sinulaflexiolides A-K, cembrane-type diterpenoids from the Chinese soft coral Sinularia flexibilis

被引：52

作者：

Wen, Ting ^{[1
]}

Ding, Yi ^{[2
]}

Deng, Zhiwei ^{[3
]}

van Ofwegen, Leen P. ^{[4
]}

Proksch, Peter ^{[5
]}

Lin, Wenhan ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China

[3] Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100875, Peoples R China

[4] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands

[5] Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 07期

关键词：

D O I：

10.1021/np070640g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A-K (1-11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 mu M, respectively.

引用

页码：1133 / 1140

页数：8

共 25 条

[1] Cardiac and vascular responses of isolated rat tissues treated with diterpenes from Sinularia flexibilis (Coelenterata: Octocorallia) [J].

Aceret, TL ;

Brown, L ;

Miller, J ;

Coll, JC ;

Sammarco, PW .

TOXICON, 1996, 34 (10) :1165-1171

[2] Antimicrobial activity of the diterpenes flexibilide and sinulariolide derived from Sinularia flexibilis Quoy and Gaimard 1833 (Coelenterata: Alcyonacea, Octocorallia) [J].

Aceret, TL ;

Coll, JC ;

Uchio, Y ;

Sammarco, PW .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1998, 120 (01) :121-126

[3] Flexibilolide and dihydroflexibilolide, the first trihydroxycembranolide lactones from the soft coral Sinularta flexibilis of the Indian Ocean [J].

Anjaneyulu, ASR ;

Sagar, KS .

NATURAL PRODUCT LETTERS, 1996, 9 (02) :127-135

[4] New cembranoid lactones from the Indian Ocean soft coral Sinularia flexibilis [J].

Anjaneyulu, ASR ;

Sagar, KS ;

Rao, GV .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (01) :9-12

[5] Syntheses of (+)-alismoxide and (+)-4-epi-alismoxide [J].

Blay, Gonzalo ;

Garcia, Begona ;

Molina, Eva ;

Pedro, Jose R. .

JOURNAL OF ORGANIC CHEMISTRY, 2006, 71 (20) :7866-7869

[6]

Duh Chang-Yih, 1995, Acta Oceanographica Taiwanica, V34, P71

[7] A novel cytotoxic biscembranoid from the formosan soft coral Sinularia flexibilis [J].

Duh, CY ;

Wang, SK ;

Tseng, HK ;

Sheu, JH .

TETRAHEDRON LETTERS, 1998, 39 (39) :7121-7122

[8] Cytotoxic cembranoids from the soft corals Sinularia gibberosa and Sarcophyton trocheliophorum [J].

Duh, CY ;

Hou, RS .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (06) :595-598

[9] Novel cytotoxic cembranoids from the soft coral Sinularia flexibilis [J].

Duh, CY ;

Wang, SK ;

Tseng, HK ;

Sheu, JH ;

Chiang, MY .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (06) :844-847

[10] THE STRUCTURE OF A NOVEL CEMBRANOID DITERPENE FROM A PHILIPPINE COLLECTION OF THE SOFT CORAL SINULARIA-FLEXIBILIS [J].

GUERRERO, PP ;

READ, RW ;

BATLEY, M ;

JANAIRO, GC .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (08) :1185-1191

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