Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications

被引：283

作者：

Johnson, Jeremiah A. ^{[1
]}

Lu, Ying Y. ^{[1
]}

Van Deventer, James A. ^{[1
]}

Tirrell, David A. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Joseph J Jacobs Inst Mol Engn Med, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 06期

关键词：

TRANSFER-RNA SYNTHETASE; NEWLY SYNTHESIZED PROTEINS; ESCHERICHIA-COLI; MAMMALIAN-CELLS; GENETIC-CODE; RECOMBINANT PROTEINS; FLUORESCENT PROTEIN; IN-VIVO; VISUALIZATION; METATHESIS;

D O I：

10.1016/j.cbpa.2010.09.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Residue-specific incorporation of non-canonical amino acids into proteins allows facile alteration and enhancement of protein properties. In this review, we describe recent technical developments and applications of residue-specific incorporation to problems ranging from elucidation of biochemical mechanisms to engineering of protein-based biomaterials. We hope to inform the reader of the ease and broad utility of residue-specific non-canonical amino acid incorporation with the goal of inspiring investigators outside the field to consider applying this tool to their own research.

引用

页码：774 / 780

页数：7

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