Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

被引：442

作者：

Debets, Marjoke F. ^{[1
]}

van Berkel, Sander S. ^{[1
]}

Schoffelen, Sanne ^{[1
]}

Rutjes, Floris P. J. T. ^{[1
]}

van Hest, Jan C. M. ^{[1
]}

van Delft, Floris L. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 01期

关键词：

FREE TRIAZOLE FORMATION; FREE CLICK CHEMISTRY; PROTEIN PEGYLATION; POLYMER; STRATEGIES; LIGATION; PEPTIDE; TOOL;

D O I：

10.1039/b917797c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

引用

页码：97 / 99

页数：3

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