DNA translocation in inorganic nanotubes

被引：267

作者：

Fan, R

Karnik, R

Yue, M

Li, DY

Majumdar, A ^{[1
]}

Yang, PD

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA

[3] Lawrence Berkeley Lab, Div Mat Sci, Berkeley, CA 94720 USA

来源：

NANO LETTERS | 2005年 / 5卷 / 09期

关键词：

D O I：

10.1021/nl0509677

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inorganic nanotubes were successfully integrated with microfluidic systems to create nanofluldic devices for single DNA molecule sensing. Inorganic nanotubes are unique in their high aspect ratio and exhibit translocation characteristics in which the DNA is fully stretched. Transient changes of ionic current indicate DNA translocation events. A transition from current decrease to current enhancement during translocation was observed on changing the buffer concentration, suggesting interplay between electrostatic charge and geometric blockage effects. These inorganic nanotube nanofluidic devices represent a new platform for the study of single biomolecule translocation with the potential for integration into nanofluidic circuits.

引用

页码：1633 / 1637

页数：5

共 19 条

[1] DNA-mediated fluctuations in ionic current through silicon oxide nanopore channels [J].