New bioactive clerodane diterpenoids from the roots of Casearia membranacea

被引：28

作者：

Chen, Ching-Yu ^{[1
]}

Cheng, Yuan-Bin ^{[2
]}

Chen, Shun-Ying ^{[3
]}

Chien, Ching-Te ^{[3
]}

Kuo, Yao-Haur ^{[4
]}

Guh, Jih-Hwa ^{[5
]}

Khalil, Ashraf Taha ^{[5
]}

Shen, Ya-Ching ^{[5
]}

机构：

[1] Tzu Hui Inst Technol, Ctr Gen Educ, Kaohsiung, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[3] Taiwan Forestry Res Inst, Div Silviculture, Taipei, Taiwan

[4] Natl Res Inst Chinese Med, Taipei, Taiwan

[5] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10764, Taiwan

来源：

CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 01期

关键词：

D O I：

10.1002/cbdv.200890007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Bioassay-guided fractionation of the acetone extract of the roots of Casearia membranacea furnished three new clerodane diterpenes, caseamembrins S-U (1-3) and the known caseamembrin Q (4). Their structures were established by extensive spectroscopic analyses, especially 2D-NMR. Compounds 1-4 were tested against human tumor cells, including HeLa (cervical epitheloid carcinoma), DLD-1 (colon carcinoma), Daoy (medulloblastoma), and KB (oral epidermoid carcinoma) cell lines. Caseamembrin T (2) exhibited the most potent activity against Daoy cells (ED50 = 10 ng/ml), superior to that of the standard drug mitomycin.

引用

页码：162 / 167

页数：6

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