A total synthesis of epothilones using solid-supported reagents and scavengers

被引：58

作者：

Storer, RI ^{[1
]}

Takemoto, T ^{[1
]}

Jackson, PS ^{[1
]}

Ley, SV ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 22期

关键词：

aldol reaction; antitumor agents; natural products; polyketides; polymers;

D O I：

10.1002/anie.200351413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A total synthesis of epothilone C(1) with concomitant formal synthesis of epothilone A is described, using immobilized reagents and scavengers to effect multistep synthetic transformations and purifications.

引用

页码：2521 / 2525

页数：5

共 87 条

[31]

Kowalski RJ, 1997, J BIOL CHEM, V272, P2534

[32]

KOWALSKI RJ, 1995, MOL BIOL CELL, V6, P2137

[33] Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation [J].

Ley, SV ;

Baxendale, IR ;

Bream, RN ;

Jackson, PS ;

Leach, AG ;

Longbottom, DA ;

Nesi, M ;

Scott, JS ;

Storer, RI ;

Taylor, SJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (23) :3815-4195

[34]

Liu ZY, 2002, CHEM-EUR J, V8, P3747, DOI 10.1002/1521-3765(20020816)8:16<3747::AID-CHEM3747>3.0.CO

[35]

2-A

[36]

Martin HJ, 2000, ANGEW CHEM INT EDIT, V39, P581, DOI 10.1002/(SICI)1521-3773(20000204)39:3<581::AID-ANIE581>3.3.CO

[37]

2-N

[38]

MARTIN HJ, 2000, ANGEW CHEM, V112, P591

[39] Total syntheses of epothilones B and D: applications of allylstannanes in organic synthesis [J].

Martin, N ;

Thomas, EJ .

TETRAHEDRON LETTERS, 2001, 42 (47) :8373-8377

[40] Total synthesis of (-)-epothilone B [J].

May, SA ;

Grieco, PA .

CHEMICAL COMMUNICATIONS, 1998, (15) :1597-1598

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