A total synthesis of epothilones using solid-supported reagents and scavengers

被引：58

作者：

Storer, RI ^{[1
]}

Takemoto, T ^{[1
]}

Jackson, PS ^{[1
]}

Ley, SV ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 22期

关键词：

aldol reaction; antitumor agents; natural products; polyketides; polymers;

D O I：

10.1002/anie.200351413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A total synthesis of epothilone C(1) with concomitant formal synthesis of epothilone A is described, using immobilized reagents and scavengers to effect multistep synthetic transformations and purifications.

引用

页码：2521 / 2525

页数：5

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