学术探索
学术期刊
新闻热点
数据分析
智能评审

A total synthesis of epothilones using solid-supported reagents and scavengers

被引：58
作者：
Storer, RI [1 ]
Takemoto, T [1 ]
Jackson, PS [1 ]
Ley, SV [1 ]
机构：
[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 22期
关键词：
aldol reaction; antitumor agents; natural products; polyketides; polymers;
D O I：
10.1002/anie.200351413
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A total synthesis of epothilone C(1) with concomitant formal synthesis of epothilone A is described, using immobilized reagents and scavengers to effect multistep synthetic transformations and purifications.
引用
收藏
页码：2521 / 2525
页数：5
相关论文
共 87 条
[51]   An approach to epothilones based on olefin metathesis [J].
Nicolaou, KC ;
He, Y ;
Vourloumis, D ;
Vallberg, H ;
Yang, Z .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (20) :2399-2401
[52]   The olefin metathesis approach to epothilone A and its analogues [J].
Nicolaou, KC ;
He, Y ;
Vourloumis, D ;
Vallberg, H ;
Roschangar, F ;
Sarabia, F ;
Ninkovic, S ;
Yang, Z ;
Trujillo, JI .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (34) :7960-7973
[53]   Total synthesis of epothilone A: The macrolactonization approach [J].
Nicolaou, KC ;
Sarabia, F ;
Ninkovic, S ;
Yang, Z .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (05) :525-527
[54]   Total syntheses of epothilones A and B via a macrolactonization-based strategy [J].
Nicolaou, KC ;
Ninkovic, S ;
Sarabia, F ;
Vourloumis, D ;
He, Y ;
Vallberg, H ;
Finlay, MRV ;
Yang, Z .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (34) :7974-7991
[55]  
NICOLAOU KC, 1996, ANGEW CHEM, V108, P2554
[56]  
Sawada D, 2000, ANGEW CHEM INT EDIT, V39, P209, DOI 10.1002/(SICI)1521-3773(20000103)39:1<209::AID-ANIE209>3.0.CO
[57]  
2-F
[58]   Enantioselective total synthesis of epothilones A and B using multifunctional asymmetric catalysis [J].
Sawada, D ;
Kanai, M ;
Shibasaki, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (43) :10521-10532
[59]  
SAWADA D, 2000, ANGEW CHEM, V112, P215
[60]  
Schinzer D, 1999, CHEM-EUR J, V5, P2483, DOI 10.1002/(SICI)1521-3765(19990903)5:9<2483::AID-CHEM2483>3.0.CO
123456789