Helical membrane proteins: diversity of functions in the context of simple architecture

被引：74

作者：

Ubarretxena-Belandia, I ^{[1
]}

Engelman, DM ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-440X(00)00217-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past year, research on helical membrane proteins has brought insights into the use of deviations from canonical alpha -helical conformation to support function and the further investigation of the sequestration of protein regions from the lipid bilayer to enhance these structural alternatives. Also, the structural roles of polar sidechains, the identification of motifs in helix interactions and the significance of certain topologies on a genome-wide scale have been further explored.

引用

页码：370 / 376

页数：7

共 60 条

[11] Internal packing of helical membrane proteins [J].

Eilers, M ;

Shekar, SC ;

Shieh, T ;

Smith, SO ;

Fleming, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :5796-5801

[12] Membrane simulations: bigger and better? [J].

Forrest, LR ;

Sansom, MSP .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (02) :174-181

[13] Cys-scanning mutagenesis:: a novel approach to structure-function relationships in polytopic membrane proteins [J].

Frillingos, S ;

Sahin-Tóth, M ;

Wu, JH ;

Kaback, HR .

FASEB JOURNAL, 1998, 12 (13) :1281-1299

[14] Structure of a glycerol-conducting channel and the basis for its selectivity [J].

Fu, DX ;

Libson, A ;

Miercke, LJW ;

Weitzman, C ;

Nollert, P ;

Krucinski, J ;

Stroud, RM .

SCIENCE, 2000, 290 (5491) :481-486

[15] G protein-coupled receptors - II. Mechanism of agonist activation [J].

Gether, U ;

Kobilka, BK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) :17979-17982

[16] A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments [J].

Gurezka, R ;

Laage, R ;

Brosig, B ;

Langosch, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (14) :9265-9270

[17] PHOTOISOMERIZATION, ENERGY-STORAGE, AND CHARGE SEPARATION - MODEL FOR LIGHT ENERGY TRANSDUCTION IN VISUAL PIGMENTS AND BACTERIORHODOPSIN [J].

HONIG, B ;

EBREY, T ;

CALLENDER, RH ;

DINUR, U ;

OTTOLENGHI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (06) :2503-2507

[18] Structure of the Escherichia coli fumarate reductase respiratory complex [J].

Iverson, TM ;

Luna-Chavez, C ;

Cecchini, G ;

Rees, DC .

SCIENCE, 1999, 284 (5422) :1961-1966

[19] Helix packing in polytopic membrane proteins: Role of glycine in transmembrane helix association [J].

Javadpour, MM ;

Eilers, M ;

Groesbeek, M ;

Smith, SO .

BIOPHYSICAL JOURNAL, 1999, 77 (03) :1609-1618

[20] A MUTATION DATA MATRIX FOR TRANSMEMBRANE PROTEINS [J].

JONES, DT ;

TAYLOR, WR ;

THORNTON, JM .

FEBS LETTERS, 1994, 339 (03) :269-275

← 1 2 3 4 5 6 →