Copper catalyzed tandem asymmetric conjugate addition-cyclization reaction in the presence of chiral phosphoramidite ligands

被引：35

作者：

Li, KY ^{[1
]}

Alexakis, A ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 46期

基金：

新加坡国家研究基金会;

关键词：

copper; tandem; conjugate addition; cyclization; chiral; phosphoramidite ligands;

D O I：

10.1016/j.tetlet.2005.09.065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed intramolecular conjugate addition-cyclization in the presence of chiral phosphoramidite ligands was described. Cyclic products with multiple chiral centers were obtained with up to 93:7 diastereomeric ratio and 94% ee. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8019 / 8022

页数：4

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