Asymmetric conjugate addition of metal alkyl reagents catalyzed by copper complexes with BINPO: a hemilabile P,O-heterobidentate axially chiral ligand

被引:49
作者
Fuchs, N
d'Augustin, M
Humam, M
Alexakis, A
Taras, R
Gladiali, S
机构
[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy
[2] Univ Geneva, Dept Chim Organ, CH-1211 Geneva, Switzerland
关键词
D O I
10.1016/j.tetasy.2005.08.041
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
We herein report the use of a new class of P,O-bidentate arylphosphine ligand for the asymmetric copper catalyzed conjugate addition of dialkylzinc and trialkylaluminium with the enantiomeric excesses reaching 91% while (R)-muscone was obtained with 77% ee. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3143 / 3146
页数:4
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