Preparation and diastereoselective functionalization of a new chiral non racemic bicyclic hydrazinolactam

被引：15

作者：

Roussi, F

Bonin, M

Chiaroni, A

Micouin, L

Riche, C

Husson, HP

机构：

[1] Univ Paris 05, Fac Sci Pharmaceut & Biol, CNRS, Chim Therapeut Lab, F-75270 Paris 06, France

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(98)01813-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting with R-(-)-phenylglycinol, the synthesis of a new bicyclic hydrazinolactam 3 was realized on a multigram scale. The reaction scope of the corresponding enolate with various electrophiles has been studied. Good to excellent diastereoselectivities were obtained. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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页码：8081 / 8084

页数：4

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