Heat shock factors: integrators of cell stress, development and lifespan

被引:1051
作者
Akerfelt, Malin [1 ,2 ]
Morimoto, Richard I. [3 ]
Sistonen, Lea [1 ,2 ]
机构
[1] Abo Akad Univ, Dept Biosci, FIN-20520 Turku, Finland
[2] Univ Turku, Ctr Biotechnol, FIN-20520 Turku, Finland
[3] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Rice Inst Biomed Res, Evanston, IL 60208 USA
基金
芬兰科学院;
关键词
DNA-BINDING DOMAIN; TRANSCRIPTION FACTOR HSF1; RNA-POLYMERASE-II; INDUCED NUCLEAR-BODIES; IN-VIVO; CAENORHABDITIS-ELEGANS; MOLECULAR CHAPERONES; TARGETED DISRUPTION; ACTIVATION DOMAINS; SUMO MODIFICATION;
D O I
10.1038/nrm2938
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.
引用
收藏
页码:545 / 555
页数:11
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