Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus

被引：38

作者：

Lane, Amy L.

Stout, Elizabeth P.

Hay, Mark E.

Prusak, Anne C.

Hardcastle, Kenneth

Fairchild, Craig R.

Franzblau, Scott G.

Le Roch, Karine

Prudhomme, Jacques

Aalbersberg, William

Kubanek, Julia ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA

[3] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

[5] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL 60612 USA

[6] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA

[7] Univ S Pacific, Inst Appl Sci, Suva, Fiji

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 19期

关键词：

D O I：

10.1021/jo071210y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoic acids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.

引用

页码：7343 / 7351

页数：9

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