Analytical methods for quality control of combinatorial libraries

被引:12
作者
Fitch, WL [1 ]
机构
[1] Affymax Res Inst, Santa Clara, CA 95051 USA
关键词
analytical chemistry; combinatorial chemistry; infrared spectroscopy; magic angle spinning; mass spectrometry; nuclear magnetic resonance spectroscopy; solid phase organic chemistry;
D O I
10.1023/A:1009683610173
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This literature review covers the applications of analytical techniques to solid phase organic chemistry and combinatorial chemistry published between June 96 and September 1997. Highlighted are mass spectrometry, NMR, IR and chromatographic analyses of solid phase synthesis reactions and combinatorial libraries.
引用
收藏
页码:39 / 45
页数:7
相关论文
共 59 条
[1]  
[Anonymous], ANGEW CHEM INT EDIT, DOI DOI 10.1002/ANIE.199622881
[2]   Spectrometrically monitored selection experiments: Quantitative laser desorption mass spectrometry of small chemical libraries [J].
Berlin, K ;
Jain, RK ;
Tetzlaff, C ;
Steinbeck, C ;
Richert, C .
CHEMISTRY & BIOLOGY, 1997, 4 (01) :63-77
[3]   Polymer-supported quenching reagents for parallel purification [J].
Booth, RJ ;
Hodges, JC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) :4882-4886
[4]   Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries [J].
Brummel, CL ;
Vickerman, JC ;
Carr, SA ;
Hemling, ME ;
Roberts, GD ;
Johnson, W ;
Weinstock, J ;
Gaitanopoulos, D ;
Benkovic, SJ ;
Winograd, N .
ANALYTICAL CHEMISTRY, 1996, 68 (02) :237-242
[5]   Photolytic mass laddering for fast characterization of oligomers on single resin beads [J].
Burgess, K ;
Martinez, CI ;
Russell, DH ;
Shin, H ;
Zhang, AJ .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (17) :5662-5663
[6]   Direct monitoring of organic reactions on polymeric supports [J].
Carrasco, MR ;
Fitzgerald, MC ;
Oda, Y ;
Kent, SBH .
TETRAHEDRON LETTERS, 1997, 38 (36) :6331-6334
[7]   High throughput on-bead monitoring of solid phase reactions by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) [J].
Chan, TY ;
Chen, R ;
Sofia, MJ ;
Smith, BC ;
Glennon, D .
TETRAHEDRON LETTERS, 1997, 38 (16) :2821-2824
[8]   The solid-phase combinatorial synthesis of beta-thioketones [J].
Chen, CX ;
Randall, LAA ;
Miller, RB ;
Jones, AD ;
Kurth, MJ .
TETRAHEDRON, 1997, 53 (19) :6595-6609
[9]   Magic angle spinning NMR for reaction monitoring and structure determination of molecules attached to multipin crowns [J].
Chin, J ;
Fell, B ;
Shapiro, MJ ;
Tomesch, J ;
Wareing, JR ;
Bray, AM .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (03) :538-539
[10]  
DEBEN IEA, 1997, MIKROCHIM ACTA S, V14, P245