Natural products targeting telomere maintenance

被引：35

作者：

Chen, Jack Li-Yang ^{[1
]}

Sperry, Jonathan ^{[1
]}

Ip, Nancy Y. ^{[2
]}

Brimble, Margaret A. ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland, New Zealand

[2] Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

来源：

MEDCHEMCOMM | 2011年 / 2卷 / 04期

关键词：

QUADRUPLEX STABILIZING LIGANDS; LEUKEMIA HL-60 CELLS; INDUCED APOPTOSIS; REVERSE-TRANSCRIPTASE; ANTITUMOR AGENTS; CANCER-CELLS; IN-VITRO; PROSTATE-CANCER; DOWN-REGULATION; GAMBOGIC ACID;

D O I：

10.1039/c0md00241k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are repetitive sequences of DNA found at the ends of chromosomes which determine and restrict the number of replications a cell can undertake. In the majority of cancer cells, telomerase has been found to maintain the length of telomeres, conferring cell immortality and prevention of cell senescence. With the ready availability of assays to detect telomerase activity, numerous telomerase inhibitors have been discovered from a variety of natural sources. This article gives an outline of these natural product-based telomerase inhibitors and their inspiration for analogue design.

引用

页码：229 / 245

页数：17

共 241 条

[1] UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species [J].