Thioridazine: resurrection as an antimicrobial agent?

被引:66
作者
Thanacoody, H. K. R. [1 ]
机构
[1] Royal Infirm, Edinburgh, Midlothian, Scotland
关键词
antimicrobial; drug development; drug resistance; QT prolongation; thioridazine; tuberculosis;
D O I
10.1111/j.1365-2125.2007.03021.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The emergence of multiresistant bacterial strains and the continuing burden of infectious disease globally point to the urgent need for novel affordable antimicrobial drugs. Thioridazine is a phenothiazine antipsychotic drug with well-recognized antimicrobial activity, but this property has not been harnessed for clinical use as a result of its central nervous system and cardiac side-effects. The cardiotoxicity of thioridazine has recently been shown to be structurally specific at a molecular level, whereas its antimicrobial properties are shared by a number of phenothiazine analogues. This raises the possibility that its enantiomers or its inactive metabolite, the ring sulphoxide, may act as a lead compound in the future development of antimicrobial drugs to face the new challenges in infectious disease.
引用
收藏
页码:566 / 574
页数:9
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