Efficient synthesis of the azaspirocyclic core structure of halichlorine and pinnaic acid by intramolecular acylnitroso ene reaction

被引：44

作者：

Matsumura, Y ^{[1
]}

Aoyagi, S ^{[1
]}

Kibayashi, C ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 18期

关键词：

D O I：

10.1021/ol030073y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new efficient strategy for the construction of the 6-azaspiro[4.5]decane ring system was developed using intramolecular ene reaction of the acylnitroso compound. The spirocyclic ene product obtained as a single diastereomer was subsequently subjected to highly stereoselective ethynylation, leading to the azaspirodecane core of halichlorine and the pinnaic acids.

引用

页码：3249 / 3252

页数：4

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