The meter of metabolism

被引：727

作者：

Green, Carla B. ^{[2
]}

Takahashi, Joseph S. ^{[1
,3
,4
]}

Bass, Joseph ^{[3
,4
,5
,6
,7
]}

机构：

[1] Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA

[2] Univ Virginia, Dept Biol, Charlottesville, VA 22904 USA

[3] Northwestern Univ, Ctr Funct Genom, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Med, Evanston, IL 60208 USA

[6] Evanston Hosp Corp, Evanston NW Healthcare Res Inst, Evanston, IL 60208 USA

[7] Evanston Hosp Corp, Dept Med, Evanston, IL 60208 USA

来源：

CELL | 2008年 / 134卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.cell.2008.08.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes.

引用

页码：728 / 742

页数：15

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