Metastasis: a therapeutic target for cancer

被引：263

作者：

Steeg, Patricia S. ^{[1
]}

Theodorescu, Dan ^{[2
]}

机构：

[1] NCI, Womens Canc Sect, Mol Pharmacol Lab, Ctr Canc Res, Bethesda, MD 20892 USA

[2] Univ Virginia, Paul Mellon Urol Canc Inst, Charlottesville, VA 22908 USA

来源：

NATURE CLINICAL PRACTICE ONCOLOGY | 2008年 / 5卷 / 04期

关键词：

angiogenesis; bone; colonization; metastasis; tumorigenesis;

D O I：

10.1038/ncponc1066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis remains the major driver of mortality in patients with cancer. Our growing body of knowledge regarding this process provides the basis for the development of molecularly targeted therapeutics aimed at the tumor cell or its interaction with the host microenvironment. Here we discuss the similarity and differences between primary tumors and metastases, pathways controlling the colonization of a distant organ, and incorporation of antimetastatic therapies into clinical testing.

引用

页码：206 / 219

页数：14

共 98 条

[1] Prospective identification of tumorigenic breast cancer cells
Al-Hajj, M
Wicha, MS
Benito-Hernandez, A
Morrison, SJ
Clarke, MF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
[2] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis
Al-Mehdi, AB
Tozawa, K
Fisher, AB
Shientag, L
Lee, A
Muschel, RJ
[J]. NATURE MEDICINE, 2000, 6 (01) : 100 - 102
[3] Heterogeneity within and between primary colorectal carcinomas and matched metastases as revealed by analysis of Ki-ras and p53 mutations
Albanese, I
Scibetta, AG
Migliavacca, M
Russo, A
Bazan, V
Tomasino, RM
Colomba, P
Tagliavia, M
La Farina, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 325 (03) : 784 - 791
[4] Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-β type I receptor kinase inhibitor
Bandyopadhyay, Abhik
Agyin, Joseph K.
Wang, Long
Tang, Yuping
Lei, Xiufen
Story, Beryl M.
Cornell, John E.
Pollock, Bradley H.
Mundy, Gregory R.
Sun, Lu-Zhe
[J]. CANCER RESEARCH, 2006, 66 (13) : 6714 - 6721
[5] Weekly docetaxel and zoledronic acid every 4 weeks in hormone-refractory prostate cancer patients
Bertelli, G
Heouaine, A
Arena, G
Botto, A
Garrone, O
Colantonio, I
Occelli, M
Fea, E
Giubergia, S
Merlano, M
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2006, 57 (01) : 46 - 51
[6] Biology of colorectal liver metastases: A review
Bird, Nigel C.
Mangnall, David
Majeed, Ali W.
[J]. JOURNAL OF SURGICAL ONCOLOGY, 2006, 94 (01) : 68 - 80
[7] Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
Biswas, Swati
Guix, Marta
Rinehart, Cammie
Dugger, Teresa C.
Chytil, Anna
Moses, Harold L.
Freeman, Michael L.
Arteaga, Carlos L.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (05) : 1305 - 1313
[8] Inhibition of transforming growth factor-β signaling in human cancer:: Targeting a tumor suppressor network as a therapeutic strategy
Biswas, Swati
Criswell, Tracy L.
Wang, Shizhen Emily
Arteaga, Carlos L.
[J]. CLINICAL CANCER RESEARCH, 2006, 12 (14) : 4142 - 4146
[9] Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer
Bochner, Bernard H.
Dalbagni, Guido
Kattan, Michael W.
Fearn, Paul
Vora, Kinjal
Seo, Hee Song
Zoref, Lauren
Abol-Enein, Hassan
Ghoneim, Mohamed A.
Bochner, Bernard H.
Dalbagni, Guido
Scardino, Peter T.
Bajorin, Dean
Skinner, Donald G.
Stein, John P.
Miranda, Gus
Gschwend, Juergen E.
Volkmer, Bjoern G.
Hautmann, Richard E.
Chang, Sam
Cookson, Michael
Smith, Joseph A.
Thalman, George
Studer, Urs E.
Lee, Cheryl T.
Montie, James
Wood, David
Puigvert, Fundacio
Palou, Juan
Fradet, Yyes
LaCombe, Louis
Simard, Pierre
Schoenberg, Mark P.
Lerner, Seth
Vazina, Amnon
Bassi, PierFrancesco
Murai, Masaru
Kikuchi, Eiji
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (24) : 3967 - 3972
[10] BODY J, 2002, CANCER S, V97, P887

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