Noreupenifeldin, a tropolone from an unidentified ascomycete

被引：18

作者：

Ayers, Sloan ^{[1
]}

Zink, Deborah L. ^{[1
]}

Powell, Joanne S. ^{[2
]}

Brown, Christine M. ^{[2
]}

Grund, Alan ^{[3
]}

Bills, Gerald F. ^{[4
]}

Platas, Gonzalo ^{[4
]}

Thompson, Donald ^{[2
]}

Singh, Sheo B. ^{[1
]}

机构：

[1] Merck Res Labs, Nat Prod Chem, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Branchburg Farm, Somerville, NJ 08876 USA

[3] Biotechn Resources, Manitowoc, WI 54220 USA

[4] CIBE, Merck Sharp & Dohme Espana, Madrid 28027, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 03期

关键词：

D O I：

10.1021/np070513k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Noreupenifeldin (2), a new monotropolone derivative of the bistropolone eupenifeldin (1), was isolated from an unidentified ascomycete by bioassay-guided fractionation as part of our search for new anthelmintics. The structure of 1 was confirmed by comparison with literature data. The structure of 2 was elucidated from MS and 1D and 2D NMR data. Compounds 1 and 2 are diastereomers of pyenidione (3) and epolone A (4), respectively. Compounds 1-3 were evaluated for their anthelmintic activity against the parasitic worm Hemonchus contortus. Compounds 1 and 3 exhibited modest in vitro activity, showing EC(90) 50 and 83 mu g/mL, respectively, in reducing motility of L3 larvae of H. contortus. Compound 2 was inactive, indicating that the second tropolone moiety is required for activity.

引用

页码：457 / 459

页数：3

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