Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset

被引：61

作者：

Chen, Zhe ^{[1
,2
]}

Bao, Linlin ^{[3
,4
]}

Chen, Cong ^{[1
,2
]}

Zou, Tingting ^{[5
]}

Xue, Ying ^{[1
,2
]}

Li, Fengdi ^{[3
,4
]}

Lv, Qi ^{[3
,4
]}

Gu, Songzhi ^{[3
,4
]}

Gao, Xiaopan ^{[1
,2
]}

Cui, Sheng ^{[1
,2
]}

Wang, Jianmin ^{[1
,2
]}

Qin, Chuan ^{[3
,4
]}

Jin, Qi ^{[1
,2
,6
]}

机构：

[1] Chinese Acad Med Sci, Inst Pathogen Biol, MOH Key Lab Syst Biol Pathogens, Beijing, Peoples R China

[2] Peking Union Med Coll, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China

[4] Peking Union Med Coll, Key Lab Human Dis Comparat Med, Minist Hlth, Beijing Key Lab Anim Models Emerging & Remerging, Beijing, Peoples R China

[5] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China

[6] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 12期

基金：

美国国家科学基金会;

关键词：

human monoclonal antibody; MERS-CoV; common marmoset; RECEPTOR-BINDING DOMAIN; MERS-COV; DROMEDARY CAMELS; SPIKE PROTEIN; INFECTION; BAT; TRANSMISSION; EFFICACY; THERAPY; HKU4;

D O I：

10.1093/infdis/jix209

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.

引用

页码：1807 / 1815

页数：9

共 49 条

[1] Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study [J].

Al-Tawfiq, Jaffar A. ;

Momattin, Hisham ;

Dib, Jean ;

Memish, Ziad A. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2014, 20 :42-46

[2] Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus [J].

Assiri, Abdullah ;

McGeer, Allison ;

Perl, Trish M. ;

Price, Connie S. ;

Al Rabeeah, Abdullah A. ;

Cummings, Derek A. T. ;

Alabdullatif, Zaki N. ;

Assad, Maher ;

Almulhim, Abdulmohsen ;

Makhdoom, Hatem ;

Madani, Hossam ;

Alhakeem, Rafat ;

Al-Tawfiq, Jaffar A. ;

Cotten, Matthew ;

Watson, Simon J. ;

Kellam, Paul ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) :407-416

[3] Evidence for Camel-to-Human Transmission of MERS Coronavirus [J].

Azhar, Esam I. ;

El-Kafrawy, Sherif A. ;

Farraj, Suha A. ;

Hassan, Ahmed M. ;

Al-Saeed, Muneera S. ;

Hashem, Anwar M. ;

Madani, Tariq A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (26) :2499-2505

[4] Emergence of Zaire Ebola Virus Disease in Guinea [J].

Baize, Sylvain ;

Pannetier, Delphine ;

Oestereich, Lisa ;

Rieger, Toni ;

Koivogui, Lamine ;

Magassouba, N'Faly ;

Soropogui, Barre ;

Sow, Mamadou Saliou ;

Keita, Sakoba ;

De Clerck, Hilde ;

Tiffany, Amanda ;

Dominguez, Gemma ;

Loua, Mathieu ;

Traore, Alexis ;

Kolie, Moussa ;

Malano, Emmanuel Roland ;

Heleze, Emmanuel ;

Bocquin, Anne ;

Mely, Stephane ;

Raoul, Herve ;

Caro, Valerie ;

Cadar, Daniel ;

Gabriel, Martin ;

Pahlmann, Meike ;

Tappe, Dennis ;

Schmidt-Chanasit, Jonas ;

Impouma, Benido ;

Diallo, Abdoul Karim ;

Formenty, Pierre ;

Van Herp, Michel ;

Guenther, Stephan .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (15) :1418-1425

[5] Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung [J].

Chen, HD ;

Fraire, AE ;

Joris, I ;

Welsh, RM ;

Selin, LK .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (04) :1341-1355

[6] Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus [J].

Chen, Zhe ;

Wang, Jianmin ;

Bao, Linlin ;

Guo, Li ;

Zhang, Weijia ;

Xue, Ying ;

Zhou, Hongli ;

Xiao, Yan ;

Wang, Jianwei ;

Wu, Fan ;

Deng, Ying ;

Qin, Chuan ;

Jin, Qi .

NATURE COMMUNICATIONS, 2015, 6

[7] Use of convalescent plasma therapy in SARS patients in Hong Kong [J].

Cheng, Y ;

Wong, R ;

Soo, YOY ;

Wong, WS ;

Lee, CK ;

Ng, MHL ;

Chan, P ;

Wong, KC ;

Leung, CB ;

Cheng, G .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2005, 24 (01) :44-46

[8] Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus [J].

Corti, Davide ;

Zhao, Jincun ;

Pedotti, Mattia ;

Simonelli, Luca ;

Agnihothram, Sudhakar ;

Fett, Craig ;

Fernandez-Rodriguez, Blanca ;

Foglierini, Mathilde ;

Agatic, Gloria ;

Vanzetta, Fabrizia ;

Gopal, Robin ;

Langrish, Christopher J. ;

Barrettg, Nicholas A. ;

Sallusto, Federica ;

Baric, Ralph S. ;

Varani, Luca ;

Zambon, Maria ;

Perlman, Stanley ;

Lanzavecchia, Antonio .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (33) :10473-10478

[9] SARS and MERS: recent insights into emerging coronaviruses [J].

de Wit, Emmie ;

van Doremalen, Neeltje ;

Falzarano, Darryl ;

Munster, Vincent J. .

NATURE REVIEWS MICROBIOLOGY, 2016, 14 (08) :523-534

[10] Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques [J].

de Wit, Emmie ;

Rasmussen, Angela L. ;

Falzarano, Darryl ;

Bushmaker, Trenton ;

Feldmann, Friederike ;

Brining, Douglas L. ;

Fischer, Elizabeth R. ;

Martellaro, Cynthia ;

Okumura, Atsushi ;

Chang, Jean ;

Scott, Dana ;

Benecke, Arndt G. ;

Katze, Michael G. ;

Feldmann, Heinz ;

Munster, Vincent J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (41) :16598-16603

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