Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates

被引：195

作者：

Parsons, Andrew T. ^{[1
]}

Senecal, Todd D. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

fluorine; homogeneous catalysis; iron; trifluoromethylation; COPPER-CATALYZED TRIFLUOROMETHYLATION; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; ALLYLIC TRIFLUOROMETHYLATION; ARYL FLUORIDES; BORONIC ACIDS; REAGENT; PERFLUOROALKYLATION; ORGANOCATALYSIS;

D O I：

10.1002/anie.201108267

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Exchanging BF 3 by CF 3: The title reaction proceeds under exceedingly mild reaction conditions and provides 2-arylvinyl- and 2-heteroarylvinyl-substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalation of the RBF 3K species to the iron catalyst. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2947 / 2950

页数：4

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