Fatal varicella associated with selective natural killer cell deficiency

被引：118

作者：

Etzioni, A ^{[1
]}

Eidenschenk, C

Katz, R

Beck, R

Casanova, JL

Pollack, S

机构：

[1] Technion Israel Inst Technol, Meyer Childrens Hosp, Dept Immunol, B Rappaport Med Sch, IL-31096 Haifa, Israel

[2] Necker Enfants Malades Med Sch, Lab Human Genet Infect Dis, Paris, France

来源：

JOURNAL OF PEDIATRICS | 2005年 / 146卷 / 03期

关键词：

D O I：

10.1016/j.jpeds.2004.11.022

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and NK activity was markedly decreased. The interleukin (IL)15/IL15R signaling pathway was intact. This case emphasizes the role of NK cells in controlling herlpes viral infection.

引用

页码：423 / 425

页数：3

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