The signaling and functions of heterodimeric bone morphogenetic proteins

被引：108

作者：

Guo, Jing ^{[2
,3
]}

Wu, Gang ^{[1
,2
]}

机构：

[1] Vrije Univ Amsterdam, Res Inst MOVE, Acad Ctr Dent Amsterdam ACTA, Dept Oral Implantol & Prosthet Dent, NL-1018 LA Amsterdam, Netherlands

[2] Univ Amsterdam, NL-1018 LA Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Res Inst MOVE, Acad Ctr Dent Amsterdam ACTA, Dept Oral Cell Biol, NL-1018 LA Amsterdam, Netherlands

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2012年 / 23卷 / 1-2期

关键词：

Heterodimeric; Homodimeric; Heterodimer; Bone morphogenetic protein; Bone; Signaling; ENHANCES OSTEOBLASTIC DIFFERENTIATION; COMBINATORIAL GENE-THERAPY; MESENCHYMAL STEM-CELLS; ACTIVITY IN-VITRO; TGF-BETA FAMILY; BMP RECEPTOR; OSTEOGENIC PROTEIN; SMAD PROTEINS; PATHWAYS; BINDING;

D O I：

10.1016/j.cytogfr.2012.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Heterodimeric bone morphogenetic proteins (BMPs) consist of disulfide-linked dimeric monomers derived from different BMP members. Owing to this specific constitution pattern, they bear high affinity to both type I and type II BMP receptors simultaneously. Meanwhile, the antagonism efficiency of extracellular antagonists to heterodimeric BMPs is also significantly lower than that to homodimeric ones. All these specific properties confer heterodimeric BMPs with distinct signaling and bio-functions that are characterized by more speediness, lower concentration/dose threshold and higher efficiency than homodimeric BMPs. Consequently, heterodimeric BMPs bear promising application potential in inducing osteogenesis. In addition, they may play indispensible roles in organogenesis. In this review, we summarize the current knowledge of heterodimeric BMPs in their signaling pathways and bio-functions. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：61 / 67

页数：7

共 75 条

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Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? [J].