Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug

被引：70

作者：

Asanuma, M ^{[1
]}

Tsuji, T ^{[1
]}

Miyazaki, I ^{[1
]}

Miyoshi, K ^{[1
]}

Ogawa, N ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Brain Sci, Okayama 7008558, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 352卷 / 01期

关键词：

methamphetamine; neurotoxicity; ketoprofen; aspirin; non-steroidal anti-inflammatory drug; microglia;

D O I：

10.1016/j.neulet.2003.08.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We examined effects of non-steroidal anti-inflammatory drugs (NSAIDs) on methamphetamine (METH)-induced neurotoxicity. Marked reduction of dopamine transporter-positive signals and accumulation of microglial cells in the striatum after METH injections (4 mg/kg x 4, i.p. with 2 h-interval) were significantly and dose-dependently attenuated by four injections of ketoprofen (2 or 5 mg/kg X 4, s.c.) given 30 min prior to each METH injection, but not by either a low or high dose of aspirin. The present results suggest that the protective effects of ketoprofen against METH-induced neurotoxicity and microgliosis might be based on its inhibitory activity on inflammatory response or on microglia activation, but not on its cyclooxygenase-inhibiting property. This provides a possible new strategy against METH-induced neurotoxicity using commonly used NSAIDs. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：13 / 16

页数：4

共 17 条

[1]

NONSTEROIDAL ANTIINFLAMMATORY DRUGS INHIBIT EXPRESSION OF THE INDUCIBLE NITRIC-OXIDE SYNTHASE GENE [J].