Suffering in silence: The tolerance of DNA damage

被引:211
作者
Friedberg, EC [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA
关键词
D O I
10.1038/nrm1781
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
When cells that are actively replicating DNA encounter sites of base damage or strand breaks, replication might stall or arrest. In this situation, cells rely on DNA-damage-tolerance mechanisms to bypass the damage effectively. One of these mechanisms, known as translesion DNA synthesis, is supported by specialized DNA polymerases that are able to catalyse nucleotide incorporation opposite lesions that cannot be negotiated by high-fidelity replicative polymerases. A second category of tolerance mechanism involves alternative replication strategies that obviate the need to replicate directly across sites of template- strand damage.
引用
收藏
页码:943 / 953
页数:11
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