Sirtuin functions in health and disease

被引：401

作者：

Yamamoto, Hiroyasu

Schoonjans, Kristina

Auwerx, Johan

机构：

[1] Univ Strasbourg 1, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[2] Univ Strasbourg 1, CNRS, INSERM, F-67404 Illkirch Graffenstaden, France

[3] Inst Clin Souris, F-67404 Illkirch Graffenstaden, France

来源：

MOLECULAR ENDOCRINOLOGY | 2007年 / 21卷 / 08期

关键词：

D O I：

10.1210/me.2007-0079

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate lysine residue on various proteins. Certain sirtuins have in addition an ADP- ribosyltransferase activity. The sirtuins are remarkably conserved throughout evolution from archaebacteria to eukaryotes. The mammalian sirtuins SIRT1 - SIRT7 are implicated in a variety of cellular functions ranging from gene silencing, over the control of the cell cycle and apoptosis, to energy homeostasis. On a whole-body level, the wide range of cellular activities of the sirtuins suggests that they could constitute therapeutic targets to combat metabolic, neurodegenerative, and proliferative diseases. Here, we review some of the recent data related to the sirtuins and discuss their mode of action, their biological role in cellular and organismal models, and their possible association to age-related human diseases.

引用

收藏

页码：1745 / 1755

页数：11

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