A skeleton of the human protein interactome

被引:14
作者
Ghavidel, A
Cagney, G
Emili, A
机构
[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada
[2] Univ Coll Dublin, Conway Inst, Dublin 2, Ireland
关键词
D O I
10.1016/j.cell.2005.09.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this issue of Cell, Wanker and colleagues (Stelzl et al., 2005) present a large-scale two-hybrid map of more than 3000 putative human protein-protein interactions. These new data will serve as an important source of information regarding individual protein partners and offer preliminary insight into the global molecular organization of human cells.
引用
收藏
页码:830 / 832
页数:3
相关论文
共 13 条
[1]   High-throughput mapping of a dynamic signaling network in mammalian cells [J].
Barrios-Rodiles, M ;
Brown, KR ;
Ozdamar, B ;
Bose, R ;
Liu, Z ;
Donovan, RS ;
Shinjo, F ;
Liu, YM ;
Dembowy, J ;
Taylor, IW ;
Luga, V ;
Przulj, N ;
Robinson, M ;
Suzuki, H ;
Hayashizaki, Y ;
Jurisica, I ;
Wrana, JL .
SCIENCE, 2005, 307 (5715) :1621-1625
[2]   Interaction network containing conserved and essential protein complexes in Escherichia coli [J].
Butland, G ;
Peregrín-Alvarez, JM ;
Li, J ;
Yang, WH ;
Yang, XC ;
Canadien, V ;
Starostine, A ;
Richards, D ;
Beattie, B ;
Krogan, N ;
Davey, M ;
Parkinson, J ;
Greenblatt, J ;
Emili, A .
NATURE, 2005, 433 (7025) :531-537
[3]   Functional proteomics mapping of a human signaling pathway [J].
Colland, F ;
Jacq, X ;
Trouplin, V ;
Mougin, C ;
Groizeleau, C ;
Hamburger, A ;
Meil, A ;
Wojcik, J ;
Legrain, P ;
Gauthier, JM .
GENOME RESEARCH, 2004, 14 (07) :1324-1332
[4]   Dynamic complex formation during the yeast cell cycle [J].
de Lichtenberg, U ;
Jensen, LJ ;
Brunak, S ;
Bork, P .
SCIENCE, 2005, 307 (5710) :724-727
[5]   A protein interaction map of Drosophila melanogaster [J].
Giot, L ;
Bader, JS ;
Brouwer, C ;
Chaudhuri, A ;
Kuang, B ;
Li, Y ;
Hao, YL ;
Ooi, CE ;
Godwin, B ;
Vitols, E ;
Vijayadamodar, G ;
Pochart, P ;
Machineni, H ;
Welsh, M ;
Kong, Y ;
Zerhusen, B ;
Malcolm, R ;
Varrone, Z ;
Collis, A ;
Minto, M ;
Burgess, S ;
McDaniel, L ;
Stimpson, E ;
Spriggs, F ;
Williams, J ;
Neurath, K ;
Ioime, N ;
Agee, M ;
Voss, E ;
Furtak, K ;
Renzulli, R ;
Aanensen, N ;
Carrolla, S ;
Bickelhaupt, E ;
Lazovatsky, Y ;
DaSilva, A ;
Zhong, J ;
Stanyon, CA ;
Finley, RL ;
White, KP ;
Braverman, M ;
Jarvie, T ;
Gold, S ;
Leach, M ;
Knight, J ;
Shimkets, RA ;
McKenna, MP ;
Chant, J ;
Rothberg, JM .
SCIENCE, 2003, 302 (5651) :1727-1736
[6]   A comprehensive two-hybrid analysis to explore the yeast protein interactome [J].
Ito, T ;
Chiba, T ;
Ozawa, R ;
Yoshida, M ;
Hattori, M ;
Sakaki, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4569-4574
[7]   Systematic interpretation of genetic interactions using protein networks [J].
Kelley, R ;
Ideker, T .
NATURE BIOTECHNOLOGY, 2005, 23 (05) :561-566
[8]   A map of the interactome network of the metazoan C-elegans [J].
Li, SM ;
Armstrong, CM ;
Bertin, N ;
Ge, H ;
Milstein, S ;
Boxem, M ;
Vidalain, PO ;
Han, JDJ ;
Chesneau, A ;
Hao, T ;
Goldberg, DS ;
Li, N ;
Martinez, M ;
Rual, JF ;
Lamesch, P ;
Xu, L ;
Tewari, M ;
Wong, SL ;
Zhang, LV ;
Berriz, GF ;
Jacotot, L ;
Vaglio, P ;
Reboul, J ;
Hirozane-Kishikawa, T ;
Li, QR ;
Gabel, HW ;
Elewa, A ;
Baumgartner, B ;
Rose, DJ ;
Yu, HY ;
Bosak, S ;
Sequerra, R ;
Fraser, A ;
Mango, SE ;
Saxton, WM ;
Strome, S ;
van den Heuvel, S ;
Piano, F ;
Vandenhaute, J ;
Sardet, C ;
Gerstein, M ;
Doucette-Stamm, L ;
Gunsalus, KC ;
Harper, JW ;
Cusick, ME ;
Roth, FP ;
Hill, DE ;
Vidal, M .
SCIENCE, 2004, 303 (5657) :540-543
[9]   Control of stochasticity in eukaryotic gene expression [J].
Raser, JM ;
O'Shea, EK .
SCIENCE, 2004, 304 (5678) :1811-1814
[10]   A human protein-protein interaction network:: A resource for annotating the proteome [J].
Stelzl, U ;
Worm, U ;
Lalowski, M ;
Haenig, C ;
Brembeck, FH ;
Goehler, H ;
Stroedicke, M ;
Zenkner, M ;
Schoenherr, A ;
Koeppen, S ;
Timm, J ;
Mintzlaff, S ;
Abraham, C ;
Bock, N ;
Kietzmann, S ;
Goedde, A ;
Toksöz, E ;
Droege, A ;
Krobitsch, S ;
Korn, B ;
Birchmeier, W ;
Lehrach, H ;
Wanker, EE .
CELL, 2005, 122 (06) :957-968