Galleria mellonella as an infection model for Campylobacter jejuni virulence

被引：65

作者：

Senior, Nicola J. ^{[1
]}

Bagnall, Mary C. ^{[2
]}

Champion, Olivia L. ^{[1
]}

Reynolds, Stuart E. ^{[3
]}

La Ragione, Roberto M. ^{[2
,4
]}

Woodward, Martin J. ^{[2
]}

Salguero, Francisco J. ^{[2
]}

Titball, Richard W. ^{[1
]}

机构：

[1] Univ Exeter, Sch BioSci, Coll Life & Environm Sci, Exeter, Devon, England

[2] Vet Labs Agcy, Addlestone, Surrey, England

[3] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[4] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 5XH, Surrey, England

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2011年 / 60卷 / 05期

关键词：

GUILLAIN-BARRE-SYNDROME; INTRACELLULAR SURVIVAL; COLONIZATION; PATHOGENESIS; PERSPECTIVE; HEMOCYTES; MOTILITY; IMMUNITY; STRAINS; DISEASE;

D O I：

10.1099/jmm.0.026658-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Larvae of Galleria mellonella (Greater Wax Moth) have been shown to be susceptible to Campylobacter jejuni infection and our study characterizes this infection model. Following infection with C. jejuni human isolates, bacteria were visible in the haemocoel and gut of challenged larvae, and there was extensive damage to the gut. Bacteria were found in the extracellular and cell-associated fraction in the haemocoel, and it was shown that C. jejuni can survive in insect cells. Finally, we have used the model to screen a further 67 C. jejuni isolates belonging to different MLST types. Isolates belonging to ST257 were the most virulent in the Galleria model, whereas those belonging to ST21 were the least virulent.

引用

页码：661 / 669

页数：9

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